Research Projects

These are some of recent projects:

1.Differentiation of embryonic stem cells to hepatocytes by using of miRNA (karimi,M.H)

2.The study of the effect of leptin and adiponectin on the expression of kisspeptins and their receptors in the isolated islet cells in rat (Azarpira,N-Hossein Aghdaei,M)

3.Evaluation of relationship between IL-23R, IL-17, IL-21 polymorphism with kidney and liver graft rejection and determination of serum level of IL-17, IL-21 by ELISA technique(Geramizadeh,B-karimi,M.H)

4.Preventive and/or ameliorative effect of dendritic cells transfected with CD40 and IL-23 specific siRNA on skin allograft rejection in mice (karimi,M.H)

5.Allogenic bone marrow derived mesenchymal stem cells for treatment of physeal cartilage defect in rabbits (Ayatollahi,M)

6.Study the relationships between TNF-α, IL-10, IL-12, and IL-17 gene polymorphisms with cytomegalovirus infection and post-transplant clinical complications in hematopoietic stem cell transplant recipients (Yaghoobi,R)

7.Diferentiation of embryonal stem cell to insulin producing cells by miRNA (Azarpira,N)

8.The effect of insulin like growth factor-I (IGF-I) and its receptor (IGF-IR) on rat liver regeneration after partial hepatectomy (Ayatollahi,M)

9.Determination of the relationships between the level of gene expression of IL-17, IL-21, IL-23 cytokines and TLR-2 in pathogenesis of HCMV in liver transplant recipients (Yaghoobi,R- karimi,M.H)

10.Effect of HLA-DRB1 matching on kidney transplantation survival in namazee hospital patients between 1385-1388 (karimi,M.H)

11.Appilication of tolerogenic dendritic cells produced by inhibition of CD40 expression using RNA interference (RNAi) nanoparticle for recovery of type 1 diabetes in mouse model (karimi,M.H)

12.Effect of tacrolimus on antioxidant status and oxidative stress in HIT-T15 beta cell lines (Azarpira,N)

13.Immunomodulatory effect of mice mesenchymal stem cells on maturation and function of dendritic cells and induction of regulatory T cells in mice (karimi,M.H)

14.In vitro differential expression of ckemokine receptor CXCR4 induced by tumor necrosis factor-alpha in human mesenchymal stem cells (Ayatollahi,M)

15.Synthesis of calcium phosphate-zirconia nanocomposite scaffold and differentiation of human endometrial adult stem cells to osteoblast for bone tissue engineering (Geramizadeh,B)

16.Differential expression of insulin like growth factor-I(IGF-I) receptor induced by tumor necrosis factor-alpha in human mesenchymal stem cells (Ayatollahi,M)

17.Insulin production by lentiviral PDX1 construct in adipocyte mesenchymal stem cells (karimi,M.H)

18.The relation between BK virus activity and nephropathy by real time PCR method in plasma samples of kidney transplant patients in Shiraz (Yaghoobi,R)

19.The evaluation of expression and role of TLR2,TLR4 in acute renal rejection (karimi,M.H)

20.Investigation of the relationship between and CD40 and IL-18 polymorphism with acute liver rejection (karimi,M.H)

21.Evaluation of human marrow-derived mesenchymal stem cells migration by the amount of secreted matrix metalloproteinase-2 after in vitro norepinephrin therapy (Ayatollahi,M)

22.Evaluation of protease effect of NS3 gene from HCV on liver inflammation as well adenoviral vector maintenance in the mice liver (karimi,M.H)

23.The improvement of isolation ,proliferation and expansion of bone marrow derived human mesenchymal stem cell (Ayatollahi,M)

24.Evaluation of the prevalence of hepatitis G virus occult infection in liver transplant patients with cryptogenic cirrhosis (Geramizadeh,B-Yaghoobi,R)

25.Influence of the effect of substances ROCK inhibitor (Y-27632), Ascorbic acid and trehalose on survival of human Wharton’s jelly stem cells after cryopreservation (Azarpira,N- Ayatollahi,M)

26.The effect of platelet rich plasma on rat liver regeneration after carbon tetrachloride (CCL4) induced injury by histological analysis (Geramizadeh,B- Ayatollahi,M)

27.Cell Therapy of type I diabetes by TGF-beta1 engineered mesenchymal stem cells (karimi,M.H)

28.Evaluation of MHL1 promoter germline methylation in 50 colorectal cancer patients with MS-HRM analysis (Geramizadeh,B)

29.Profiling the alterations in microRNA gene expression in liver transplant patients (karimi,M.H)

30.Study of the genetic diversity in non coding control region (NCCR) and VP1 gene of BK polyomavirus in renal transplant patients with nephropathy and graft rejection (Yaghoobi,R)

31.Evaluation of KCNJ11 gene variants with post liver transplant diabetes mellitus (PTDM) (Geramizadeh,B- Azarpira,N)

32.Identifying health-related nutrition barriers in hemodialysis patients and the effect of anti-inflammatory renal diet on nutritional ,inflammatory and oxidative markers (Ayatollahi,M)

33.MicroRNA profiling in patients with diffuse large B-cell lymphoma (DLBL) and identifying and potential circulatoring microRNA as a biomarker (karimi,M.H)

34.Isolation of mesenchymal stem cells from wharton’s jelly of human umbilical cord and differentiation to Islet-like clusters by growth factor and transfection with Ngn3 vector and determination of insulin producing genes in differentiated cells (Azarpira,N)

35.Association of CAT C-262T and NQO1 C609T genetic polymorphisms and risk of acute rejection of renal transplantation (karimi,M.H)

Shiraz Transplant Research Center
Transplant Research Center.Mohamad Rasulallah Research Tower
Shiraz University of Medical Sciences.Shiraz.Iran
Tel & Fax: +98-71-36473954-36281529