Shiraz Pediatric Liver Cirrhosis Cohort Study

SPLCCS

Pediatric liver transplantation center in Shiraz is the largest center in the world in terms of the number of transplants performed. Children with end stage liver diseases are referred to this center from all over the country. High number of patients with regular follow-up make them a good target for longitudinal studies. To achieve this goal, a cohort study of children with liver cirrhosis was established in 2018 by the Shiraz Transplant Research Center, Shiraz Organ Transplant Center, and pediatric department. Several meetings were held for considering various aspects of the cohort study under the supervision of Dr. Geramizadeh (Principal Investigator) and special efforts of Dr. Motazedian.

The aim of this prospective study is to evaluate the natural course of liver cirrhosis in children to determine the prognostic factors of survival in pediatric liver cirrhosis. Establishment of registration system with a research perspective helps to achieve this goal.

Specific goals

• Determining demographic and social, nutritional, and clinical and paraclinical parameters associated with liver cirrhosis in pediatric patients.

• Determining the incidence and prevalence of gastrointestinal, endocrine, neurological, infectious, renal, cardiovascular, and respiratory diseases in children with cirrhosis

• Evaluation of factors affecting the prognosis of children with cirrhosis

• Establishment of a biobank including serum, plasma, hair, nail of children with liver cirrhosis

• Establishment of a registry system for children with liver cirrhosis

Cohort core:

• Dr. Seyed Ali Malekhosseini (Transplant surgeon)

• Dr. Bita Geramizadeh (Transplant Pathologist)

• Dr. Saman Nikeghbalian (Transplant surgeon)

• Dr. Alireza Shamsaeefar (Transplant surgeon)

• Dr. Kourosh Kazemi (Transplant surgeon)

• Dr. Seyed Mohsen Dehghani (Pediatric gastroenterologist)

• Dr. Nasrin Motazedian) Community medicine specialist)

• Dr. Alireza Mirahmadizadeh(Epidemiologist)

• Dr. Negar Azarpira (Pathologist)

• Dr. Mahdokht Hossein Aghdaei (PhD in Cellular and Applied Sciences)

Cohort Colleagues

• Dr. Maryam Ataollahi (Pediatric gastroenterologist)
  Dr. Homa Ilkhanipoor (Pediatric endocrinologist)

• Dr. Mitra Basiratnia (Pediatric nephrologist)

• Dr. Hamid Nemati (Pediatric neurologist)

• Dr. Maryam Ekramzadeh(Nutritionist)

• Dr. Ramin Yaghobi (PhD in Virology)

• Dr. Maryam Aytolahi (PhD in Molecular Genetics)

• Dr. Mohammad Hossein Karimi (PhD in Immunology)